RELAXATION OF THE RENAL PELVIS FOR ENDOUROLOGICAL PROCEDURES USING ISOPROTERENOL

摘要

Relaxation of ureteral smooth muscle may improve diagnostic and therapeutic upper urinary tract endos-copy. Isoproterenol is a beta-adrenergic agonist known to cause relaxation of the upper urinary tract. Jakobsen et al (page 1934) from Aarhus, Denmark evaluated the effects of endoluminal infusion of isoproterenol on renal pelvic dynamics and on cardiovascular organs. Catheters were placed in the renal pelvis of pigs for pressure measurement and perfusion, and a catheter drained the bladder. Endoluminal perfusion with isoproterenol inhibited the pelvic pressure increase due to perfusion at ranging concentrations of isoproterenol. At a perfusion rate of 8 ml per minute the maximal effect (a 78% decrease) was achieved using 0.1 uglml isoproterenol without observation of cardiovascular side effects. All concentrations of isoproterenol caused significant inhibition of the pressure-flow relationship in a dose dependent manner.