Time matters in 1:1 resuscitations: Concurrent administration of blood:plasma and risk of death

摘要

BACKGROUND: The practice of 1:1 transfusion, administering packed red blood cells (PRBCs) with fresh frozen plasma (FFP), has been associated with improved survival. However, the reported ratios are the result of mathematical averages over 24 hours and do not necessarily represent concurrent administration. Using critical administration thresholds (CAT+) of more than 3 U of PRBC per hour to identify hemorrhaging patients, this study evaluates the effect of concurrent administration of PRBC/FFP on patient survival.