The Au(I)-Catalyzed Intramolecular Hydroarylation of Terminal Alkynes Under Mild Conditions:Application to the Synthesis of 2H-Chromenes,Coumarins, Benzofurans, and Dihydroquinolines

摘要

Operationally simple Au(I)-catalyzed intramolecular hydroarylation (IMHA) reactions of terminal alkynesthat proceed in high yield and under very mild conditionsare described. These processes involve low catalyst load-ings, mild reaction temperatures, and short reactiontimes, require no cocatalysts or additives, and allow forthe generation of a number of important heterocyclicmotifs from readily accessible starting materials.