Pd(PPh_3)_4-PEG 400 Catalyzed Protocol for theAtom-Efficient Stile Cross-Coupling Reaction ofOrganotin with Aryl Bromides

摘要

Aryl bromides (4 equiv) were coupled efficiently withorganotin (1 equiv) in an atom-efficient way using thetetra(triphenylphosphine)palladium/polyethylene glycol400 (Pd(PPh_3)_4/PEG 400) catalytic system in the presenceof sodium acetate (NaOAc) as base at 100 °C, providingexcellent yields of the corresponding functionalized bi-aryls in short reaction times.