Highly Enantioselective Synthesis of Sultams viaPd-Catalyzed Hydrogenation

摘要

Using pd(cf_3co_2)_2/(S,S)-f-Binaphane as the catalyst, anefficient enantioselective synthesis of sultams was devel-oped via asymmetric hydrogenation of the correspondingcyclic imines with high enantioselectivities. The hydro-genation products can be conveniently transformedto chiral homoallylic amines without loss of enantioselec-tivity.