An Improved Synthesis of Pyridine-Thiazole Coresof Thiopeptide Antibiotics

摘要

The oxidation of 2-methylthiazoles to 2-formylthiazolessimplifies the implementation of the Bagley variant of theBohlmann-Rahtz reaction as a key step in a concise newroute to pyridine cores of thiopeptide antibiotics.