Photocyclization of Tosylstilbenes as a KeyReaction in the Preparation of an Analogue ofthe Antitumor Agent CC-1065

Ana G. Neo; Antonio Perez; Carmen Lopez; Luis Castedo; Gabriel Tojo

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Photocyclization of Tosylstilbenes as a KeyReaction in the Preparation of an Analogue ofthe Antitumor Agent CC-1065

机译：甲苯磺酰苯的光环化作为抗肿瘤药CC-1065类似物制备中的关键反应

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A photocyclization of tosylstilbenes in the presence of baseis used as a key reaction in the synthesis of the CC-1065analogue 5.

机译：在存在碱的情况下，甲苯磺酰基对苯二甲酸酯的光环化是CC-1065模拟化合物5合成中的关键反应。

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《The Journal of Organic Chemistry》 |2009年第8期|共4页
作者
Ana G. Neo; Antonio Perez; Carmen Lopez; Luis Castedo; Gabriel Tojo;
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正文语种 eng
中图分类有机化学;
关键词
Photocyclization; Tosylstilbenes; Antitumor;

机译：光环化;甲苯磺酰苯;抗肿瘤;

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专利

1. Photocyclization of Tosylstilbenes as a KeyReaction in the Preparation of an Analogue ofthe Antitumor Agent CC-1065 [J] . Ana G. Neo, Antonio Perez, Carmen Lopez, The Journal of Organic Chemistry . 2009,第8期

机译：甲苯磺酰苯的光环化作为抗肿瘤药CC-1065类似物制备中的关键反应
2. Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders [J] . Baraldi PG, Balboni G, Pavani MG, Journal of Medicinal Chemistry . 2001,第16期

机译：设计，合成，DNA结合和对水溶性杂化分子的生物学评估，该杂化分子包含抗肿瘤药CC-1065的烷基化环丙基吡咯并吲哚（CPI）亚基的两个吡唑类似物和聚吡咯小沟粘合剂
3. STUDIES ON THE SYNTHESIS OF THE ANTITUMOR AGENT CC-1065 - PREPARATION OF ISOPROPYL 6-HYDROXY-7-METHOXY-4-(2-NITROOXYETHYL)INDOLE-2-CARBOXYLATE [J] . Castedo L., Tojo G., Marcos CF. Synthetic Communications . 1995,第11期

机译：抗氧化剂CC-1065的合成研究-异丙基6-羟基-7-甲氧基-4-（2-硝基氧乙基）吲哚-2-羧酸酯的制备
4. Structure-Activity Relationship Study of New FK228 Analogues as Antitumor Agents [C] . Salvatore Di Maro, Rey-Chen Pong, Jer-Tsong Hsieh American Peptide Symposium . 2009

机译：新FK228类似物作为抗肿瘤剂的结构 - 活动关系研究
5. Part I. Applications of inverse electron demand Diels-Alder reactions of heterocyclic azadienes: Two syntheses of Amaryllidaceae alkaloids. Part II. In situ activation of a DNA alkylating agent: Evaluation of simplified and reversed CPyI analogues of CC-1065 and the duocarmycins. Part III. Progress toward the total synthesis of cytostatin. [D] . Wolkenberg, Scott Evan. 2003

机译：第一部分。逆向电子需量的应用杂环氮杂二烯的Diels-Alder反应：金莲花科生物碱的两种合成。第二部分DNA烷化剂的原位活化：评估CC-1065和Duocarmycins的简化和反向CPyI类似物。第三部分向细胞抑制素的全合成方向发展。
6. Antitumor Agents 291 Expanded B-Ring Modification Study of 688-Triethyl Desmosdumotin B Analogues as Multidrug-Resistance Selective Agents [O] . Kyoko Nakagawa-Goto, Kenneth F Bastow, Emika Ohkoshi, -1

机译：抗肿瘤剂291扩增688-三乙基Desmosdumotin B类似物的B环改性研究如多药抗性选择性剂
7. CC-1065(NSC 298223), a potent new antitumor agent. Improved production and isolation, characterization and antitumor activity. [O] . DAVID G. MARTIN, CAROLYN BILES, SHIRLEY A. GERPHEIDE, 1981

机译：CC-1065（NSC 298223），一种有效的新抗肿瘤剂。改善生产和分离，表征和抗肿瘤活动。

Photocyclization of Tosylstilbenes as a KeyReaction in the Preparation of an Analogue ofthe Antitumor Agent CC-1065

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