IBX-I2 Redox Couple for Facile Generation of IOH and It: Expedient Protocol for Iodohydroxylation of Olefins and Iodination of Aromatics

摘要

IBX is readily reduced to IBAin the presence of moleculariodine in DMSO to generate hypoiodous acid (IOH), which reacts with a variety of olefins as well as R, -unsaturated ketones leading to their respective iodohydrins with anti stereochemistry. The same redox chemistry in acetonitrile containing TFA produces iodonium ions for facile iodination of a variety of aromatic compounds in respectable isolated yields.