Toward the Synthesis of the Rare N-(Trifluoromethyl)amides and theN-(Difluoromethylene)-N-(trifluoromethyl)amines [RN(CF_3)CF_2R']Using BrF_3

摘要

A synthesis of a wide range of different aliphatic, aromatic, and heterocyclic N-(trifluoromethyl)-amides along with aromatic N-(difluoromethylene)-N-(trifluoromethyl)amine derivatives has beendeveloped. The starting materials are the easily available isothiocyanates, and the fluorinatingreagent is the commercially available bromine trifluoride. The reaction is performed under mildconditions, and the fluorinated amides and amines are produced in moderate to high yields.