Nickel- and Rhodium-Catalyzed Addition of Terminal Silylacetylenes to Propargyl Amines:Catalyst-Dependent Complementary Regioselectivity

摘要

The cross-addition of terminal silylacetylenes to y-arylatedpropargyl amines occurs efficiently via C—H cleavage byusing either a nickel or rhodium catalyst. Taking advantageof the catalyst-controlled switching of regioselectivity in thereaction, both the 2- and 3-alkynylallylamines are readilyaccessible from the same starting materials.