Heterobimetallic Lanthanide/Sodium Phenoxides:Efficient Catalysts for Amidation of Aldehydeswith Amines

摘要

Heterobimetallic lanthanide/sodium phenoxides were foundto be efficient catalysts for amidation of aldehydes withamines under mild conditions. The reactivity follows theorder Nd < Y < Sm for metals and 2,6-(Me)2C6H3O < 2,6-(iPr)2C6H3O < 2,6-(tBu)2C6H3O for phenoxide groups. Incomparison with the corresponding monometallic complexes,heterobimetallic complexes show higher activity and a widerrange of scope of amines. A cooperation of lanthanide andsodium in this process is proposed to contribute to the highactivity of the present catalyst.