Cell cultures of rat suprachiasmatic nucleus: Circadian oscillation of vasopressin release

摘要

A dissociated cell culture system has been developed for the suprachiasmatic nucleus (SCN), in which release of vasopressin showed a clear circadian oscillation. The oscillation peaked at early subjective day and appeared within one day in culture. This system may provide a valuable model for the study of cellular and molecular mechanisms of the mammalian circadian pacemaker.