beta-Sugar Aminoxy Peptides As Rigid Secondary Structural Scaffolds

Chandrasekhar S; Rao CL; Reddy MS; Sharma GD; Kiran MU; Naresh P; Chaitanya GK; Bhanuprakash K; Jagadeesh B

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beta-Sugar Aminoxy Peptides As Rigid Secondary Structural Scaffolds

机译：β-糖胺氧基肽作为刚性二级结构支架

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摘要

Short homo-oligomers of a new building block, cis-beta(2,3)-furanoid sugar aminoxy acid. are designed, characterized. and found to exhibit rigid ribbon-like secondary structures composed of 5/7 bifurcated intramolecular hydrogen bonds.

机译：一个新的组成部分，顺-β（2,3）-呋喃糖糖胺氧基酸的短均聚物。被设计，表征。并且发现具有由5/7分叉的分子内氢键组成的刚性带状二级结构。

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《The Journal of Organic Chemistry》 |2008年第23期|共4页
作者
Chandrasekhar S; Rao CL; Reddy MS; Sharma GD; Kiran MU; Naresh P; Chaitanya GK; Bhanuprakash K; Jagadeesh B;
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正文语种 eng
中图分类有机化学;
关键词
QUATERNARY STRUCTURE; PACLITAXEL TAXOL(R); CRYSTAL-STRUCTURE; BUILDING-BLOCKS; GAMMA-PEPTIDES; ACIDS; FOLDAMERS; OLIGOMERS; HELIX; CONFORMATION;

机译：四元结构;PACXITAXEL TAXOL（R）;晶体结构;砌块;伽马肽;酸;折叠剂;低聚物;螺旋;构象;

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专利

1. beta-Sugar Aminoxy Peptides As Rigid Secondary Structural Scaffolds [J] . Chandrasekhar S, Rao CL, Reddy MS, The Journal of Organic Chemistry . 2008,第23期

机译：β-糖胺氧基肽作为刚性二级结构支架
2. Effect of structural modification of alpha-aminoxy peptides on their intestinal absorption and transport mechanism. [J] . Ma B, Zha H, Li N, Molecular pharmaceutics . 2011,第4期

机译：α-氨氧基肽的结构修饰对其肠道吸收和转运机制的影响。
3. First Peptide-Based System of Rigid Donor - Rigid Interchromophore Spacer-Rigid Acceptor: A Structural and Photophysical Study [J] . Toniolo C., Formaggio F., Crisma M., Chemistry: A European journal . 1999,第8期

机译：刚性供体的第一个基于肽的系统-刚性发色团间隔物-刚性受体：结构和光物理研究
4. SECONDARY STRUCTURAL ELEMENTS AND INTRAMOLECULAR H-BONDING PATTERNS OF POLY-(ALA) AND POLY-(GLN) PEPTIDES [C] . Balazs Leitgeb, Ferenc Bogar, Gabor Paragi the European Peptide Symposium . 2007

机译：聚 - （ALA）和聚 - （GLN）肽的二级结构元素和分子内H键合图案
5. Effect of Structural Modification on Absorption, Metabolism and Pharmacokinetics of alpha-Aminoxy Peptides. [D] . Ma, Bin. 2011

机译：结构修饰对α-氨氧基肽的吸收，代谢和药代动力学的影响。
6. A Fluorescent Protein Scaffold for Presenting Structurally Constrained Peptides Provides an Effective Screening System to Identify High Affinity Target-Binding Peptides [O] . Tetsuya Kadonosono, Etsuri Yabe, Tadaomi Furuta, -1

机译：用于呈现结构受限肽的荧光蛋白支架提供了有效的筛选系统以鉴定高亲和力的目标结合肽。
7. A fluorescent protein scaffold for presenting structurally constrained peptides provides an effective screening system to identify high affinity target-binding peptides. [O] . Tetsuya Kadonosono, Etsuri Yabe, Tadaomi Furuta, 2014

机译：用于呈递结构受限肽的荧光蛋白支架提供了有效的筛选系统以鉴定高亲和力靶结合肽。

beta-Sugar Aminoxy Peptides As Rigid Secondary Structural Scaffolds

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