Synthesis of fused 4,5-disubstituted indole ring systems by intramolecular Friedel-Crafts acylation of 4-substituted indoles

摘要

4-Substituted indoles containing a variety of electrophiles and N-substituents undergo Friedel-Crafts acylation to give exclusively the products of cyclization at the 5-position of indole. These indanones and tetralones have been scarcely prepared and are subunits in natural products and analogues of potential biological significance.