Synthesis of Indole Alkaloid Analogues: Novel Domino Stereoselective Electrophile Addition-Cyclizations of Tryptophan-Derived alpha-Amino Nitriles

Juan A. Gonzalez-Vera; M. Teresa Garcia-Lopez; Rosario Herranz

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Synthesis of Indole Alkaloid Analogues: Novel Domino Stereoselective Electrophile Addition-Cyclizations of Tryptophan-Derived alpha-Amino Nitriles

机译：吲哚生物碱类似物的合成：色氨酸衍生的α-氨基腈的新型多米诺立体选择性亲电加成环化反应

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The synthesis of new indole alkaloid analogues, containing a 1,2,4,5,10b, 10c-hexahydropyrrolo[1',2',3':1,9a,9]imidazo-[1,2-a]indole skeleton, via highly stereoselective novel domino cyclative halogenation or prenylation reactions of tryptophan-derived alpha-amino nitriles, is described.

机译：包含1,2,4,5,10b，10c-六氢吡咯并[1'，2'，3'：1,9a，9]咪唑-[1,2-a]吲哚骨架的新吲哚生物碱类似物的合成，通过色氨酸衍生的α-氨基腈的高度立体选择性的新型多米诺环化卤化或异戊烯化反应进行了描述。

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《The Journal of Organic Chemistry》 |2007年第14期|共4页
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Juan A. Gonzalez-Vera; M. Teresa Garcia-Lopez; Rosario Herranz;
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入库时间 2022-08-18 18:30:04

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1. Synthesis of Indole Alkaloid Analogues: Novel Domino Stereoselective Electrophile Addition-Cyclizations of Tryptophan-Derived alpha-Amino Nitriles [J] . Juan A. Gonzalez-Vera, M. Teresa Garcia-Lopez, Rosario Herranz The Journal of Organic Chemistry . 2007,第14期

机译：吲哚生物碱类似物的合成：色氨酸衍生的α-氨基腈的新型多米诺立体选择性亲电加成环化反应
2. Synthesis of indole alkaloid analogues containing the novel hexahydropyrrolo[1′,2′,3′:1,9a,9]imidazo[1,2-a]indole skeleton by ring-closing reactions of tryptophan-derived α-amino nitriles [J] . Juan A. Gonzalez-Vera, M. Teresa Garcia-Lipez, Rosario Herranz Tetrahedron . 2007,第37期

机译：通过色氨酸衍生的α-氨基腈的闭环反应合成含有新型六氢吡咯并[1'，2'，3'：1,9a，9]咪唑[1,2-a]吲哚骨架的吲哚生物碱类似物
3. Unprecedented Stereospecific Synthesis of a Novel Tetracyclic Ring System,a Hybrid of Tetrahydropyrrolo[2,3-b]indole and Tetrahydroimidazo[1,2-a]indole,via a Domino Reaction upon a Tryptophan-Derived Amino Nitrile [J] . Juan A.Gonzalez-Vera, M.Teresa Garcia-Lopez, Rosario Herranz Organic letters . 2004,第16期

机译：通过色氨酸衍生的氨基腈的多米诺反应，前所未有地合成新型四环系统，即四氢吡咯并[2,3-b]吲哚和四氢咪唑并[1,2-a]吲哚的混合物
4. Stereoselective Synthesis of Axially ChiralC-N Bonds in N-Aryl Indoles and Acridanes [C] . Ken Kamikawa, Akiyoshi Mori, Shunsuke Kinoshita Symposium on Organometallic Chemistry . 2008

机译：基于芳基吲哚和吖啶碱基轴向Chiralc-N键的立体选择性合成
5. Part I. General approach to the total synthesis of 9-methoxy substituted indole alkaloids: Total synthesis of the opioid agonistic indole alkaloid, mitragynine as well as 9-methoxy-geissoschizol and 9-methoxy-N(b)-methylgeissoschizol. Part II. Studies toward the total synthesis of the antimalarial bisindole alkaloid villastonine. [D] . Ma, Jun. 2006

机译：第一部分。9-甲氧基取代的吲哚生物碱的总合成的一般方法：阿片类激动剂吲哚生物碱，米塔吉宁以及9-甲氧基-Geissoschizol和9-甲氧基-N（b）-甲基Geissoschizol的总合成。第二部分对抗疟药双吲哚生物碱坏死精的全合成的研究。
6. Stereospecific Approach to the Synthesis of Ring-A Oxygenated Sarpagine Indole Alkaloids. Total Synthesis of the Dimeric Indole Alkaloid P-(+)-Dispegatrine and Six Other Monomeric Indole Alkaloids [O] . Chitra R. Edwankar, Rahul V. Edwankar, Ojas A. Namjoshi, -1

机译：立体定向方法合成环A氧化的Sarpagine吲哚生物碱。二聚吲哚生物碱P-（+）-Dispegatrine和其他六个单体吲哚生物碱的全合成
7. Stereoselective synthesis of the Indole Alkaloids Nitrarine, Nitramidine and Isomers. A Biomiometic approach. [O] . Wanner, M.J., Koomen, G.J. 1994

机译：吲哚生物碱硝胺，硝胺和异构体的立体选择性合成。仿生方法。

Synthesis of Indole Alkaloid Analogues: Novel Domino Stereoselective Electrophile Addition-Cyclizations of Tryptophan-Derived alpha-Amino Nitriles

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