Mechanism study of copper-mediated one-pot reductive amination of aryl halides using trimethylsilyl azide

摘要

Reaction mechanisms of the copper-mediated amination of aryl halides with trimethylsilyl azide (TMSN_3) were analyzed on the basis of the time-course study using reaction monitoring FT-IR, trapping an intermediary aryl azide by the Huisgen reaction, and the analysis of the generated N_2 gas during the reaction. This amination would proceed through multiple pathways via aryl radicals and copper(I) azide.