Palladium-Catalyzed α?Arylation of Aryloxyketones for the Synthesis of 2,3-Disubstituted Benzofurans?

摘要

A highly efficient palladium-catalyzed α-arylation of aryloxyketones has been developed, allowing for facile installation of various (hetero)aryl groups at C2 position in good to excellent yields. Subsequent cyclodehydration of the resulting α-arylated aryloxyketones provided rapid access to diverse 2,3-disubstitured benzofurans.