Diastereoselective synthesis of dihydropyrans via prins cyclization of enol ethers: Total asymmetric synthesis of (+)-civet cat compound

摘要

Trimethylsilyl trifluoromethanesulfonate (TMSOTf) can be efficiently used for Prins cyclization of acrylyl enol ethers to 5,6-dihydro-2H-pyran-2-acetates stereo- and regioselectively in good yields. The methodology was used for the total synthesis of natural product (+)-civet.