Palladium-catalyzed double carbonylation using near stoichiometric carbon monoxide: Expedient access to substituted ~(13)C _2-labeled phenethylamines

摘要

A novel and general approach for ~(13)C _2- and 2H-labeled phenethylamine derivatives has been developed, based on a highly convergent single-step assembly of the carbon skeleton. The efficient incorporation of two carbon-13 isotopes into phenethylamines was accomplished using a palladium-catalyzed double carbonylation of aryl iodides with near stoichiometric carbon monoxide.