RuH _2(CO)(PPh _3) _3 catalyzed selective formation of 1,4-disubstituted triazoles from cycloaddition of alkynes and organic azides

摘要

The ruthenium hydride complex RuH _2(CO)(PPh _3) _3 was found to be an effective catalyst for the cycloaddition reactions of terminal alkynes and azides. In the presence of RuH _2(CO)(PPh _3) _3, various azides reacted with a range of terminal alkynes to produce 1,4-disubstituted 1,2,3-triazoles with 100% selectivity and moderate to excellent yields.