Synthesis of 2-alkyl- and aryl-3-ethoxycarbonyl-2,5-dihydrofurans through gold-catalyzed intramolecular hydroalkoxylation

摘要

Treatment of a wide range of functionalized hydroxyallenic esters with 5 mol % Ph_3PAuCl and 5 mol % AgOTf in CH_2Cl_2 at 25 °C for 1 h produced selectively 2-alkyl- and aryl-3-ethoxycarbonyl-2,5- dihydrofurans in good to excellent yield through intramolecular hydroalkoxylation by a 5-endo mode.