Lewis acid-catalyzed cyclization of enaminones with propargylic alcohols: Regioselective synthesis of multisubstituted 1,2-dihydropyridines

摘要

A highly efficient BF_3·Et_2O-catalyzed cascade reaction of enaminones with propargylic alcohols under mild reaction conditions has been developed. This methodology offers regioselective access to multisubstituted 1,2-dihydropyridines in good to excellent yields.