Measurements of Heavy-Atom Isotope Effects Using ~1H NMR Spectroscopy

摘要

A novel method for measuring heavy-atom KIEs for magnetically active isotopes using ~1H NMR is presented. It takes advantage of the resonance split of the protons coupled with the heavy atom in the ~1H spectrum. The method is validated by the example of the ~(13)C-KIE on the hydroamination of styrene with aniline, catalyzed by phosphine-ligated palladium triflates.