Stereoselective OsO4-Catalyzed Oxidative Cyclization of 1,5-Dienes

摘要

Tetrahydrofuran derivatives are an important building block of biologically active molecules from both natural origin as well as from non-natural substances. Therefore, the motif of 2,5-disubstituted tetrahydrofurans can be found in a remarkable number of natural products of different classes, e.g., annonaceous acetogenins such as membrarollin or cis-sylvaticin, squalene-derived metabolites such as glabrescol, and polyether antibiotics such as monensin A (Chart 1).1-6 These molecules potentially possess important biological activities, e.g., cytotoxic antitumor activity.