Role of OATP1B3 in the transport of bile acids assessed using first-trimester trophoblasts

Yan Ziru; Li Eqiong; He Lingfei; Wang Jianhua; Zhu Xiaojun; Wang Hanzhi; Wang Zhengping

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Role of OATP1B3 in the transport of bile acids assessed using first-trimester trophoblasts

机译：OATP1B3在胆汁酸运输中的作用，使用早孕滋养细胞进行评估

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AimsThe aim of this study was to investigate the transport of two kinds of bile acids by organic anion transporting polypeptide 1B3 (OATP1B3) using first-trimester trophoblasts. The mechanisms of damage to fetuses with intrahepatic cholestasis of pregnancy were investigated, providing new potential strategies for targeted therapies aimed at reducing fetal risk.

机译：目的本研究的目的是研究使用早孕滋养细胞通过有机阴离子转运多肽1B3（OATP1B3）转运两种胆汁酸的方法。研究了妊娠肝内胆汁淤积对胎儿的伤害机制，为旨在降低胎儿风险的靶向治疗提供了新的潜在策略。

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《The journal of obstetrics and gynaecology research》 |2015年第3期|共10页
作者
Yan Ziru; Li Eqiong; He Lingfei; Wang Jianhua; Zhu Xiaojun; Wang Hanzhi; Wang Zhengping;
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正文语种 eng
中图分类妇产科学;
关键词
bile acids; lentivirus; MTT method; organic anion transporting polypeptides; placenta;

机译：胆汁酸;慢病毒;MTT法;有机阴离子转运多肽;胎盘;

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1. Role of OATP1B3 in the transport of bile acids assessed using first-trimester trophoblasts [J] . Yan Ziru, Li Eqiong, He Lingfei, The journal of obstetrics and gynaecology research . 2015,第3期

机译：OATP1B3在胆汁酸运输中的作用，使用早孕滋养细胞进行评估
2. Alteration in placental expression of bile acids transporters OATP1A2, OATP1B1, OATP1B3 in intrahepatic cholestasis of pregnancy [J] . Huimin Wang, Ziru Yan, Minyue Dong, Archives of Gynecology and Obstetrics . 2012,第6期

机译：妊娠肝内胆汁淤积性胆汁酸转运蛋白OATP1A2，OATP1B1，OATP1B3胎盘表达的变化
3. Lysophosphatidic acid up-regulates expression of growth-regulated oncogene-alpha, interleukin-8, and monocyte chemoattractant protein-1 in human first-trimester trophoblasts: possible roles in angiogenesis and immune regulation. [J] . Chen SU, Chou CH, Chao K Endocrinology . 2010,第1期

机译：溶血磷脂酸上调人早孕滋养细胞中生长调节的癌基因-α，白介素8和单核细胞趋化蛋白-1的表达：在血管生成和免疫调节中的可能作用。
4. Extrahepatocytic transport of bile acids: the role of the cholangiocyte [C] . X. XEA, G. ALPINI, G. LeSAG International Bile Acid Meeting . 2007

机译：胆汁酸的脱脂酸：胆管细胞的作用
5. Role of Bile Acids and Compensatory Hepatic Transport Proteins in Troglitazone-Mediated Hepatotoxicity. [D] . Marion, Tracy L. 2011

机译：胆汁酸和补偿性肝转运蛋白在曲格列酮介导的肝毒性中的作用。
6. Structural requirements of the human sodium-dependent bile acid transporter (hASBT): Role of 3- and 7-OH moieties on binding and translocation of bile acids [O] . Pablo M. González, Carlos F. Lagos, Weslyn C. Ward, -1

机译：人类钠依赖性胆汁酸转运蛋白（hASBT）的结构要求：3-和7-OH部分对胆汁酸结合和转运的作用
7. Role of the Intestinal Bile Acid Transporters in Bile Acid and Drug Disposition [O] . Paul A. Dawson 2010

机译：肠胆汁酸转运蛋白在胆汁酸和药物置剂中的作用
8. Bile Acids and Lipid Metabolism Ii. Essential Role of Bile Acids in Bile Phospholipid Excretion [R] . Entenman, C., Holloway, R. J., Albright, M. L., 1968

机译：胆汁酸和脂质代谢Ii。胆汁酸在胆汁磷脂排泄中的重要作用

Role of OATP1B3 in the transport of bile acids assessed using first-trimester trophoblasts

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