Universal approach to the synthesis of juvenoid hydroprene and methoprene from 4-methyl tetrahydropyran

摘要

A universal approach to the synthesis of juvenoid hydroprene and methoprene was developed on the basis of monoalkylation of acetoacetate by 1-acetoxy-5-bromo-3-methylpentane, the product of acidic decyclization of 4-methyltetrahydropyran.