SECONDARY METABOLITES OF Peyronellaea sp. XW-12, AN ENDOPHYTIC FUNGUS OF Huperzia serrata

摘要

Fungi have long been regarded as rich sources of novel bioactive natural products. The 20th century has witnessed the discovery, isolation, and chemical characterization of a vast diversity of natural products from fungi [1]. Endophytic fungi serve as typical examples of special-habitat fungi by residing in the inner tissue of the plants and maintaining a state of balanced antagonism with the hosts. During the past two decades, endophytic fungi have been proved to be an untapped source of new bioactive natural products since a large number of natural products with novel structures and interesting biological activities was reported [2-4]. As part of our ongoing studies on endophytic fungi from Huperzia serrata [5-9], one strain Peyronellaea sp. XW-12 was characterized and subjected to chemical investigation. The fungus was cultured in 12 Erlenmeyer flasks (500 mL) containing solid-state medium (rice 80 g, distilled water 100 mL, each; soak overnight before autoclaving) at 28℃ for 30 days.