Reagent optimization for allylic oxidation of 3-O-acetyl-β-boswellic acid into 3-O-acetyl-11-oxo-β-boswellic acid

摘要

Introduction of the oxo group at the allylic position of 3-acetoxy-urs-12-en-24β-oic acid (ABA) in the presence of the sensitive 3α-acetyl group, thereby converting it into 3-acetoxy-urs-12-en-11-oxo- 24β-oic acid (AKBA), has been tried with various catalytic oxidizing agents. Among them sodium chlorite with N-hydroxyphthalimide and manganese(III) acetate with t-butyl hydroperoxide were found to be good reagents showing excellent conversion with functional group compatibility.