AMINOMETHYLATION OF CYTISINE BY 3-HETARYL-7-HYDROXYCOUMARINS

摘要

8-Aminomethyl derivatives of 7-hydroxycoumarins were prepared by reaction of methylene-bis-cytisine and substituted 7-hydroxycoumarins.Cytisine (1) is used in western countries as a diuretic [1] and in countries of the former Soviet Union as a respiratory analeptic and anti-smoking drug [2].Such varied biological activity has generated great interest in cytisine derivatives.