Deoxypegan-1-one derivatives. Synthesis and borohydride reduction of 3-[(E)-arylmethyledene]-3,9-dihydropyrrolo[2,1-b]quinazolin-1(2H)-ones

摘要

3-[(E)-Arylmethylidene]-3,9-dihydropyrrolo[2,1-b]quinazolin-1(2H)-ones were prepared by reaction of quinazolyl-2-propionic acid hydrochloride with aromatic aldehydes in acetic anhydride in the presence of Et3N. 3-[(E)-Arylmethylidene],2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-1-ols were formed by reduction of the 3-arylidene derivatives with sodium borohydride in methanol, readily lost water when heated with acids, and were converted into 3-[(E)-arylmethylidene]-3,9-dihydropyrrolo[2,1-b]quinazolines.