Synthesis, characterization, and NF-κB pathway inhibition of 1-halogenated sinomenine derivatives

摘要

A series of 1-halogenated sinomenine derivatives was designed and prepared. All synthesized derivatives were structurally confirmed by ESI-MS, PMR. The inhibition of the NF-κB pathway in vitro was evaluated with pNF-κB-luc cell lines. The derivatives 5b, 6a, 6c, and 7a inhibited NF-κB action with IC50 values lower than that of sinomenine.