ANTIPARASITIC ACTIVITY OF CERTAIN ISOQUINOLINE ALKALOIDS AND THEIR HYPOTHETICAL COMPLEXES WITH OLIGONUCLEOTIDES

摘要

The antiparasitic activity of two tetrahydrodiisoquinoline alkaloids 2, 3, beta-allocryptopine (4), protopine (5), and a substituted phenylethylamine 6 was studied. Compounds 2 and 6 inhibited the growth of the parasite Leishmania donovani. The capability of the examined compounds to bind DNA was estimated by molecular modeling. It has been shown that binding occurs in the small groove and primarily at the AT-enriched part of the oligonucleotide.