Buddledin C from Pulicaria prostrata and selective synthesis of its epoxy derivative

摘要

The structure of the sesquiterpene ketone buddledin C isolated from Pulicaria prostrata (Gilib.)Aschers., was confirmed by XSA. The stereochemistry of its epoxide, which was formed selectively by treating it with hydrogen peroxide in alkaline solution, was proposed based on quantum-chemical and molecular-mechanical calculations.