Gated Cardiac 13N-NH3 PET for Assessment of Left Ventricular Volumes, Mass, and Ejection Fraction: Comparison with Electrocardiography-Gated 18F-FDG PET.

摘要

The purpose of this study was to evaluate myocardial electrocardiography (ECG)-gated (13)N-ammonia ((13)N-NH(3)) PET for the assessment of cardiac end-diastolic volume (EDV), cardiac end-systolic volume (ESV), left ventricular (LV) myocardial mass (LVMM), and LV ejection fraction (LVEF) with gated (18)F-FDG PET as a reference method. METHODS: ECG-gated (13)N-NH(3) and (18)F-FDG scans were performed for 27 patients (23 men and 4 women; mean +/- SD age, 55 +/- 15 y) for the evaluation of myocardial perfusion and viability. For both (13)N-NH(3) and (18)F-FDG studies, a model-based image analysis tool was used to estimate endocardial and epicardial borders of the left ventricle on a set of short-axis images and to calculate values for EDV, ESV, LVEF, and LVMM. RESULTS: The LV volumes determined by (13)N-NH(3) and (18)F-FDG were 108 +/- 60 mL and 106 +/- 63 mL for ESV and 175 +/- 71 mL and 169 +/- 73 mL for EDV, respectively. The LVEFs determined by (13)N-NH(3) and (18)F-FDG were 42% +/- 13% and 41% +/- 13%, respectively. The LVMMs determined by (13)N-NH(3) and (18)F-FDG were 179 +/- 40 g and 183 +/- 43 g, respectively. All P values were not significant, as determined by paired t tests. A significant correlation was observed between (13)N-NH(3) imaging and (18)F-FDG imaging for the calculation of ESV (r = 0.97, SEE = 14.1, P < 0.0001), EDV (r = 0.98, SEE = 15.4, P < 0.0001), LVEF (r = 0.9, SEE = 5.6, P < 0.0001), and LVMM (r = 0.93, SEE = 15.5, P < 0.0001). CONCLUSION: Model-based analysis of ECG-gated (13)N-NH(3) PET images is accurate in determining LV volumes, LVMM, and LVEF. Therefore, ECG-gated (13)N-NH(3) can be used for the simultaneous assessment of myocardial perfusion, LV geometry, and contractile function.