Using pramipexole in neuropsychiatry: a cautionary note.

摘要

SIR: Recent reports have recommended using the D2/D3 agonist pramipexole as a treatment for various psychiatric disorders such as depression in Parkinson's disease, treatment-resistant depression and bipolar depression.1""3 These reports have not adequately emphasized the psychiatric toxicity of pramipexole. While hallucinations have been described as side effects of pramipexole,4 there are few reports of other psychotic symptoms such as delusions. A recent case report described delusional jealousy arising in the context of mania.5 We report a case of acute nonaffective psychosis with delusional jealousy developing on pramipexole treatment of Holmes' tremor, remitting on stopping the drug, relapsing on rechal-lenge with a lower dose and gradually remitting with complete stoppage.