PHENOLIC ACIDS AND ANTIOXIDANT ACTIVITIES OF DANSHEN INJECTION

摘要

A chemical study on the constituents of Danshen injection (lyophilized powder) led to the isolation of 15 compounds, including 13 phenolic acids, (R)-salvianolic acid G methyl ester (1), (R)-salvianolic acid G (2), tournefolic acid B (3), isosalvianolic acid C methyl ester (4), rosmarinic acid (5), and 8 simple phenolics (6-13), together with 5-hydroxymethyl-2-furaldehyde (14) and 5-oxopyrrolidine-2-carboxylic acid (15). Among them, compound 1 was new, and 10 compounds showed potent antioxidant activities by in vitro DPPH~· and ABTS~(·+) scavenging methods with microplate assays.