Synthesis and calming activity of 9-(4-β-D-allopyranosyloxyphenyl)- decahydroacridine-1,8-dione derivatives

摘要

Seven helicid derivatives containing decahydroacridine-1,8-dione were prepared via the reactions between 1,3-cyclohexanedione or 5,5-dimethyl-1,3- cyclohexanedione and the corresponding Schiff base. The structures of the helicid derivatives were characterized by IR, ~1H NMR, and HR-MS spectrum. The target compounds were evaluated by their hypnotic-sedative activity in vivo. The preliminary bioassay tests showed that some of the compounds had more potent activity than that of helicid.