Catalytic transfer hydrogenation of mycoepoxydiene

摘要

Catalytic transfer hydrogenation with hydrogenolysis of mycoepoxydiene (1) by ammonium formate/10% Pd-C gave a new compound, deacetylhexahydromycoepoxydiene (2), whose structure was determined by spectroscopic and X-ray diffraction experiments. In the primary bioassay, 1, 2 and hexahydromycoepoxydiene (3) showed anticancer activities against HeLa in vitro. The IC50 (mu g/mL) values were 5.5, 50, and > 100, respectively.