NF-#kappa#B-Inducing Kinase Is Dispensable for Activation of NF-#kappa#B in Inflammatory Settings but Essential for lymphotoxin #beta# Receptor Activatio of NF-#kappa#B in Primary Human Fibroblasts

摘要

the transcription factor NF-#kappa#B is of major importance in the biology of pro-inflammatory cytokines, such as TNF-#alpha# and IL-1#alpha#, and thereby is intimately involved in the process of inflammation.