Chemical constituents from the mangrove endophytic fungus Sporothrix sp.

摘要

The genus Sporothrix is an anamorph of the genus Ophiostoma, which includes the human pathogen Sporothrix schenckii and various species that are associated with insects and cause sap stain of wood [1]. Earlier research mainly focused on the morphological characteristics of the Sporothrix species. A few metabolites have been documented for Sporothrix species, Nakanishi et al. obtained two new inhibitors KS-501 and KS-502 of Ca~(2+) from Sporothrix sp. KAC-1985 [2]; 4-methyl-7,11- heptadecadienal and 4-methyl-7,11-heptadecadienoic acid have been reported from Sporothrix flocculosa and Sporothrix rugulosa [3]; Takamatsu et al. isolated a cytocidal antibiotic, chlovalicin, produced by the Sporothrix sp. FO-4649 [4]; Carlos et al. reported a lipid compound from the cell wall of Sporothrix schenchii that induced high liberation of NO and TNF-R in macrophage cultures [5]. In this study, we describe the isolation and identification of 24 compounds from the mangrove endophytic fungus Sporothrix sp. (#4335).