Synthesis of fluorine-containing 3-hydroxyflavanones and isoflavones

摘要

Fluorine-containing 3-hydroxyflavanones and isoflavones were synthesized by epoxidation of F-containing chalcones by hydrogen peroxide under basic conditions and subsequent intramolecular cyclization of the resulting epoxides using BF _3·Et _2O. The ratio of products depended on the presence and position of the F atom.