首页> 外文期刊>The Journal of Comparative Neurology >Dual morphology and topography of the corticothalamic terminals originating from the primary, supplementary motor, and dorsal premotor cortical areas in macaque monkeys.
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Dual morphology and topography of the corticothalamic terminals originating from the primary, supplementary motor, and dorsal premotor cortical areas in macaque monkeys.

机译:起源于猕猴的初级,辅助运动和背运动前皮质区域的皮质丘脑末端的双重形态和形貌。

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In the motor, somatosensory, and auditory systems of rodents and cats, the corticothalamic connection is composed of a main projection formed by small endings and a minor projection terminating with giant endings. To establish whether the corticothalamic projection originating from motor cortical areas in primates exhibits the same duality, the anterograde tracer biotinylated dextran amine was injected in eight macaque monkeys in the primary motor (M1; n = 3), the supplementary motor (SMA; n = 3) and the dorsal premotor (PMd; n = 2) cortical areas to label corticothalamic axons. The corticothalamic projection originating from these three motor cortical areas was characterized by the presence of axon terminals constituting the same two types of endings, observed both as boutons en passant and terminaux. The population of small endings exhibited a mean cross-sectional maximum diameter of 0.95 microm (S.D. = 0.23), a range of diameters not overlapping that of giant endings (mean diameter = 3.46 microm, S.D. = 0.74 microm). Topographically, the giant endings originating from M1 were located in the same thalamic nucleus (ventroposterolateral nucleus, oral part) in which the small endings were found. In contrast, the giant endings originating from SMA and PMd were located in a thalamic nucleus (mediodorsal nucleus) distinct from the main termination zone formed by small endings. Along the rostrocaudal axis, the giant endings were distributed in a restricted zone, irrespective of the origin of the projection (M1, SMA, PMd). The dual morphology of corticothalamic endings, previously found in rodents and cats, is present in the motor system of subhuman primates for both primary and nonprimary motor cortical areas.
机译:在啮齿动物和猫的运动,体感和听觉系统中,皮层丘脑连接由一个由小末端形成的主突起和一个由大末端终止的小突起组成。为了确定源自灵长类动物运动皮层区域的皮质丘脑投射是否表现出相同的对偶性,在主要运动者(M1; n = 3),辅助运动者(SMA; n =)中的八只猕猴中注射顺铂示踪剂生物素化的葡聚糖胺。 3)和背侧前运动(PMd; n = 2)皮质区域标记皮质丘脑轴突。源自这三个运动皮质区域的皮质丘脑突突的特征在于,存在着轴突末端,它们构成了相同的两种类型的末端,无论是通过还是通过末端都可以观察到。小末端的种群显示的平均横截面最大直径为0.95微米(标准偏差= 0.23),其直径范围不与大末端的重叠(平均直径= 3.46微米,标准偏差= 0.74微米)。在地形上,源自M1的巨大末端位于发现小末端的同一丘脑核(腹膜外侧核,口腔部分)中。相反,源自SMA和PMd的巨大末端位于丘脑核(中嗅核),与由小末端形成的主要终止区域不同。沿杆尾轴,巨型末端分布在受限区域中,与投影的起点(M1,SMA,PMd)无关。先前在啮齿动物和猫中发现的皮质丘脑末端的双重形态存在于初级和非初级运动皮质区域的亚人类灵长类动物的运动系统中。

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