Control of extracellular protease activity in brain function

摘要

Serine proteases are considered to be involved in plasticity-related events in the nervous system, but their in vivo targets and the importance of their control by endogenous inhibitors are still not clarified. This article describes the crucial roleof a potent inhibitor of serine proteases, namely protease nexin-1 (PN-1), in the regulation of activity-dependent brain proteolysis and the functioning of sensory pathways.