Combined ultrasound-targeted microbubble destruction and polyethylenimine-mediated plasmid DNA delivery to the rat retina: enhanced efficiency and accelerated expression

Li Hongli; Qian Jin; Yao Chunfang; Wan Caifeng; Li Fenghua

首页> 外文期刊>The journal of gene medicine >Combined ultrasound-targeted microbubble destruction and polyethylenimine-mediated plasmid DNA delivery to the rat retina: enhanced efficiency and accelerated expression

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Combined ultrasound-targeted microbubble destruction and polyethylenimine-mediated plasmid DNA delivery to the rat retina: enhanced efficiency and accelerated expression

机译：结合超声靶向的微泡破坏和聚乙烯亚胺介导的质粒DNA传递至大鼠视网膜：提高效率和加速表达

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BackgroundGene therapy has potential in the treatment of refractory retinal diseases. It is important to develop an effective delivery system in the retina. The present study aimed to investigate the efficacy and safety of ultrasound (US)-targeted microbubble destruction (UTMD)-mediated polyethylenimine (PEI) to the rat retina.

机译：背景技术基因疗法在治疗难治性视网膜疾病方面具有潜力。在视网膜中开发有效的递送系统非常重要。本研究旨在研究针对大鼠视网膜的超声（US）靶向微泡破坏（UTMD）介导的聚乙烯亚胺（PEI）的功效和安全性。

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《The journal of gene medicine》 |2016年第6期|共10页
作者
Li Hongli; Qian Jin; Yao Chunfang; Wan Caifeng; Li Fenghua;
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正文语种 eng
中图分类医学遗传学;
关键词
kinetic of expression; microbubble; retina gene therapy; target delivery; transfection efficiency; ultrasound;

机译：表达动力学;微泡;视网膜基因治疗;靶标递送;转染效率;超声;

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1. Combined ultrasound-targeted microbubble destruction and polyethylenimine-mediated plasmid DNA delivery to the rat retina: enhanced efficiency and accelerated expression [J] . Li Hongli, Qian Jin, Yao Chunfang, The journal of gene medicine . 2016,第4a6期

机译：结合超声靶向的微泡破坏和聚乙烯亚胺介导的质粒DNA传递至大鼠视网膜：提高效率和加速表达
2. Ultrasound-targeted microbubble destruction enhances polyethylenimine-mediated gene transfection in vitro in human retinal pigment epithelial cells and in vivo in rat retina [J] . Wan Caifeng, Qian Jin, Li Fenghua, Molecular medicine reports . 2015,第2aPta1期

机译：超声靶向微胶石破碎增强了人视网膜色素上皮细胞体外的聚乙烯亚胺介导的基因转染，在大鼠视网膜中体内
3. Ultrasound-Targeted Microbubble Destruction Delivery of Insulin-Like Growth Factor 1 cDNA and Transforming Growth Factor Beta Short Hairpin RNA Enhances Tendon Regeneration and Inhibits Scar Formation In Vivo [J] . Xiang Xi, Leng Qianying, Tang Yuanjiao, Human gene therapy. Clinical development . 2018,第4期

机译：超声靶向微胶石破坏胰岛素样生长因子1 cDNA和转化生长因子β短发夹RNA增强肌腱再生并抑制体内瘢痕形成
4. Enhanced gene transfection of plasmid DNA in the liver with ultrasound and microbubbles [C] . Seip Ralf, Raju Balasundar I., Leyvi Evgeniy, 2010 IEEE International Ultrasonics Symposium . 2010

机译：超声和微泡增强肝脏中质粒DNA的基因转染
5. A novel, DNA-based alphavirus gene expression system for rapid recombinant protein purification and virus-based gene delivery to retina and retinoblastoma tumor cells. [D] . DiCiommo, David Patrick. 2002

机译：一种新颖的，基于DNA的α病毒基因表达系统，用于快速重组蛋白纯化和基于病毒的基因传递至视网膜和视网膜母细胞瘤肿瘤细胞。
6. Tissue Targeting and Ultrasound-Targeted Microbubble Destruction Delivery of Plasmid DNA and Transfection In Vitro [O] . Yue Wang, Xiaoli Li, Lanlan Liu, 2020

机译：组织靶向和超声靶向微泡销毁质粒DNA的递送和体外转染
7. Ultrasound-targeted microbubble destruction enhances AAV mediated gene transfection: human RPE cells in vitro and the rat retina in vivo [O] . Hongli Li, Xiaozhi Zheng, Huiping Wang, 2009

机译：超声靶向微泡破坏增强AAV介导的基因转染：体外人RPE细胞和体内大鼠视网膜

Combined ultrasound-targeted microbubble destruction and polyethylenimine-mediated plasmid DNA delivery to the rat retina: enhanced efficiency and accelerated expression

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