Immunoglobulin A anti-BP230 autoantibodies in linear immunoglobulin A/immunoglobulin G bullous dermatosis.

摘要

Linear immunoglobulin (lg)A bullous dermatosis (LABD) is an autoimmune subepidermal bullous disease characterized by linear IgA deposits at the epidermal basement membrane zone (BMZ). Immunoblot analyses have shown a variety of corresponding antigens with molecular weights of mainly 97, 120, 180 and 290 kDa.2'3 Most LABD sera react with the epidermal side (lamina lucida type), and a few LABD sera react with the dermal side (sublamina densa type) on NaCI split skin. Most patients of lamina lucida type show IgA autoantibodies against the 97 or 120 kDa LAD-1, which is a degradation product of the extracellular domain of BP180.