Pilot study on photodynamic therapy for acne using chlorophyll: Evaluator-blinded, split-face study

摘要

Since its ability of producing radical oxygen species was known, chlorophyll's usefulness in photodynamic therapy (PDT) for acne has received great attention (1,2). However, the effect of chlorophyll-PDT for acne has not been reported in the literature so far.We investigated the efficacy and safety of PDT with chlorophyll in four patients (one female, three males) with mild to moderate acne. Exclusion criteria included: (i) age under 18 years; (ii) cystic acne; (iii) photosensitivity; (iv) recent use of photosensitizing agents; (v) use of oral acne treatments within 4 weeks or topical acne treatments within 2 weeks, use of isotretinoin within 6 months; and (vi) pregnancy or lactation. After vigorous scrubbing with acetone and comedone extraction, a 19% a,b-chlorophyll solution (Delta-blue?; Korea Rub, Korea) was applied randomly onto the right or left side of the face.