Effects of intra-aortic ballon pumping on renal sympathetic nerve activity and renal circulation in dogs.

摘要

BACKGROUND: Little is known on how intra-aortic balloon pumping (IABP) affects neural circulatory regulation, even though many studies have been done to clarify the effects of IABP on hemodynamics. Although IABP is used clinically in patients with severe heart failure, whose sympathetic nerve activity is increased, there are no previous reports that demonstrate the effects of IABP on neural regulation in heart failure. The aim of this study is to determine the effects of IABP on neural regulation of renal circulation with both normal and failing heart condition in dogs. METHODS: We directly measured renal sympathetic nerve activity and hemodynamic parameters (heart rate, central venous pressure, distal aortic pressure, proximal aortic pressure, left ventricular pressure, renal sympathetic nerve activity, ascending aortic flow, and renal arterial flow) before and during IABP driving in both normal and failing heart condition in dogs (n=7). Acute heart failure models were made by coronary ligation. RESULTS: IABP driving inhibits renal sympathetic nerve activity and improves renal circulation in failing heart condition, while these phenomena do not occur in normal heart condition. CONCLUSIONS: These findings suggest that IABP may show its full effect on renal circulation via neural regulation especially in failing heart condition.