Mesenchymal Stem Cells Secrete Brain-Derived Neurotrophic Factor and Promote Retinal Ganglion Cell Survival After Traumatic Optic Neuropathy

Li Junyi; Li Na; Jiang Yan

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Mesenchymal Stem Cells Secrete Brain-Derived Neurotrophic Factor and Promote Retinal Ganglion Cell Survival After Traumatic Optic Neuropathy

机译：创伤性视神经病变后，间充质干细胞分泌脑源性神经营养因子并促进视网膜神经节细胞存活。

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Objective: The study aimed to investigate whether intravitreal injection of mesenchymal stem cells (MSCs) cultivated in vitro could increase the number of survived retinal ganglion cells (RGCs) after traumatic optic neuropathy and sought to identify potential mechanisms underlying such growth.

机译：目的：本研究旨在探讨玻璃体腔注射体外培养的间充质干细胞（MSC）是否可以增加创伤性视神经病变后存活的视网膜神经节细胞（RGC）的数量，并试图找出这种生长的潜在机制。

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《The Journal of craniofacial surgery》 |2015年第2期|共5页
作者
Li Junyi; Li Na; Jiang Yan;
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正文语种 eng
中图分类口腔科学;
关键词
Mesenchymal stem cells; brain-derived neurotrophic factor; retinal ganglion cells; traumatic optic neuropathy;

机译：间充质干细胞;脑源性神经营养因子;视网膜神经节细胞;外伤性视神经病变;

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专利

1. Mesenchymal Stem Cells Secrete Brain-Derived Neurotrophic Factor and Promote Retinal Ganglion Cell Survival After Traumatic Optic Neuropathy [J] . Li Junyi, Li Na, Jiang Yan The Journal of craniofacial surgery . 2015,第2期

机译：创伤性视神经病变后，间充质干细胞分泌脑源性神经营养因子并促进视网膜神经节细胞存活。
2. Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of axotomized retinal ganglion cells in adult rats: comparison to and combination with brain-derived neurotrophic factor (BDNF). [J] . Yan Q, Wang J, Matheson CR, Journal of neurobiology . 1999,第3期

机译：胶质细胞源性神经营养因子（GDNF）促进成年大鼠轴突化视网膜神经节细胞的存活：与脑源性神经营养因子（BDNF）比较并与之结合。
3. Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo [J] . Vincent Pernet1 and Adriana Di Polo12 Brain . 2006,第4期

机译：脑源性神经营养因子与晶状体损伤的协同作用促进视网膜神经节细胞存活，但在体内导致视神经营养不良
4. Effect of transplantation of bone marrow mesenchymal stem cells on the expression of nerve growth factor and brain-derived neurotrophic factor in rats after sciatic nerve crush injury [C] . Hua Xin, Guang Yang 2011 International Conference on Human Health and Biomedical Engineering . 2011

机译：骨髓间充质干细胞移植对坐骨神经挤压伤大鼠神经生长因子和脑源性神经营养因子表达的影响
5. Brain-derived neurotrophic factor promotes retinal ganglion cell survival and reduces tyrosine receptor kinase B protein andmRNA in vivo. [D] . Chen, Hao. 2001

机译：脑源性神经营养因子在体内可促进视网膜神经节细胞存活并减少酪氨酸受体激酶B蛋白和mRNA。
6. Upregulation of Brain-Derived Neurotrophic Factor by application of Fibroblast Growth Factor-2 to the cut optic nerve is important for long term survival of retinal ganglion cells [O] . Rosa E. Blanco, Ileana Soto, Mildred Duprey-Díaz, -1

机译：通过将成纤维细胞生长因子-2应用于视神经切断可上调脑源性神经营养因子对于视网膜神经节细胞的长期存活很重要
7. Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo [O] . Vincent Pernet, Adriana Di Polo 2006

机译：脑衍生的神经营养因子和镜片损伤的协同作用促进视网膜神经节细胞存活，但导致体内视神经营养不良症

Mesenchymal Stem Cells Secrete Brain-Derived Neurotrophic Factor and Promote Retinal Ganglion Cell Survival After Traumatic Optic Neuropathy

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