A simple and efficient approach to the synthesis of furopyran derivatives: Four-component reaction of isocyanides with arylidene-substituted Meldrum's acid

摘要

A four-component (3+1) reaction of an alkyl isocyanide with arylidene-substituted Meldrum's acid in CH_2Cl_2 at room temperature produced furo[3,4-b]pyran-5(7H)-one derivatives in good yields. The structures of the synthesized compounds were confirmed by IR, NMR spectroscopy, mass spectra, and elemental analysis.