JBIR-124: A novel antioxidative agent from a marine sponge-derived fungus Penicillium citrinum SpI080624G1f01

摘要

Active oxygen species cause many diseases such as atherosclerosis, inflammation, ischemia-reperfusion injury, rheumatoid arthritis and central nervous diseases.1 Furthermore, senility and cancer initiation and progression are also believed to involve active oxygen species.2 Thus, it is expected that effective antioxidative agents may prevent the onset and development of these diseases. In the course of our screening program for novel antioxidants, we have already reported the isolation of a new sorbicillinoid derivative, designated JBIR-59,3 from cultures of Penicillium citrinum SpI080624GlfOl isolated from marine sponges collected offshore of Ishigaki Island, Okinawa Prefecture, Japan. Further screening of the cultures resulted in the isolation of a new JBIR-59 derivative designated as JBIR-124 (1, Figure 1). This paper describes the isolation, structure elucidation and brief biological activity of 1.